Objectives: The objective was to determine if stress will have effect on mental health of patients in Kaduna. To find out if stress will significantly predict mental health of patients in Kaduna.

Method: A total of 60 participants comprising 41 males and 19 females were selected through purposive sampling technique from the Federal Neuropsychiatric Hospital, Kaduna. The two instruments used were Patient Health Questionnaire (PHQ) and Perceived Stress Scale (PSS) which were administered by a Psychiatrist and a Clinical Psychologist. Two hypotheses were tested using inferential statistics of Linear Regression and Multiple Regression test to infer the significant among the variables.

Results: The result of hypothesis one showed that perceived stress was a significant positive predictor of mental health, R² = .214, F(1, 58) = 15.84, p < .001. Hypothesis two indicated that the two predictors cumulatively explained approximately 21.8% of the variance in mental health scores, R² = .218, F(2, 57) = 7.94, p = .001.

Conclusion: The study concluded that, there was a significant positive association of perceived stress on mental health among patients.